Stem cell biomarkers

Cancer stem cells are cells found in tumors that have the ability to propagate the tumor after its dissociation.  In some tumors, this property is expressed by a large fraction of the total tumor cells, meaning abundant cancer stem cells.  However, in many tumors the cancer stem cell fraction is small, mimicking the smaller fractions of stem cells in normal adult tissues.  This distribution of cancer stem cells has captured the imagination of cancer scientists.  There is speculation that cancer stem cells at low fractions in tumors may be responsible for cancer drug resistance, metastasis, and tumor recurrence.
Due to the widely-held importance of cancer stem cells in cancer development and treatment, there is considerable interest in identifying, quantifying, and investigating them.  However, because of the inherent heterogeneity of human tumor cellularity, the search for cancer stem cell specific biomarkers has been even more fraught with false positives than the search for specific biomarkers for normal tissue stem cells.

  • Cancer diagnostics and biomarkers
  • Organ cancer: breast, oral, head and neck Cancer
  • Myeloid, Lymphoid leukemia’s
  • Cancer treatments

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