Margarita Glazova
Russian Academy of Sciences
Russia
Title: Intrinsic role of p53 in the differentiation of neural stem cells
Biography
Biography: Margarita Glazova
Abstract
p53 is a tumor suppressor protein that induces cell cycle arrest, senescence, or apoptosis in response to cellular stresses. Recent studies suggest the involvement of p53 also in the regulation of neural stem cell self-renewal and differentiation. However, our knowledge about molecular mechanisms of the p53-mediated neuronal differentiation is still limited. The purpose of this study was to reveal the signaling pathways involved in p53-mediated neuronal differentiation. Recently, we demonstrated that p53 deficiencies affected not only on the functional activity of mature neurons of hypothalamus, but also differentially changed the cell’s populations. Moreover, our and others data demonstrated that p53 can induce MAPK activity, the well-known pathway involved in NSC differentiation. Our study was performed on neural progenitors isolated from the hippocampus of new-born mice.The obtained data demonstrated that p53 acts on neural differentiation in cooperation with MAPK. Moreover, the results revealed that GSK3b also mediates the effects of p53. This work was supported by grant RFBR 13-04-01431-a.
