Reinaldo Geraldo
Federal University of Juiz de Fora, Brazil
Title: Platelet Activity: The assessment profi le in patients with sicle-cell hemoglobinopathy and the antiplatelet potential of synthetic compounds
Biography
Biography: Reinaldo Geraldo
Abstract
Platelets and erythrocytes are blood elements involved in important pathologies such as the hemoglobinopathies, thrombosis and occlusive processes, and they may be both correlated to them. The treatment of these pathologies is a science purpose as the current options present risks and collateral effects. This work purpose was to produce a review about platelets and erythrocytes and their participation in some pathology, also describing a brief study about these elements and a hemoglobinopathy patient. We also identified some molecules with an antiplatelet profile on rabbit blood from three new acylhidrazones and pirazole-piridine serie synthetized by Alice Bernardino and Vitor Ferreira groups from Instituto de Química da UFF (Labiomol AM serie) and Luiza Dias e Maria Abadia Di Vaio groups from Faculdade de Farmácia da UFF (Labiomol LHa e Labiomol LHb serie), using ADP, arachidonic acid and collagen as agonists. The LabiomolLHa serie was the most promising on platelet assay induced by arachidonic acid, where Labiomol LHa 41, 43, 62, 65, 66, 67 e 130 compounds were able to totally inhibit the platelet aggregation.
