Purwati Armand
Airlangga University, Indonesia
Title: Direct implantation of adipose derived neuron progenitor stem cell to treat parkinson
Biography
Biography: Purwati Armand
Abstract
Brain in control centre of the body, this organ has a wide range of responsibilities from coordinating our movement to manage our emotion, the brain does it all. For almost hundred years it has been a mantra of biology that brain cell do not regenerate so need to add new neuron when the brain injury but stem cell niche will induce endogenous stem cell in SVZ to regenerate it. Stem cell niche with content of GABA, FGFs, EGF, VEGF, PEDF. Parkinson’s involves the malfunction and death of vital nerve cells in the brain, called neurons. Parkinson's primarily affects neurons in an area of the brain called the substantia nigra. Some of these dying neurons produce dopamine, a chemical that sends messages to the part of the brain that controls movement and coordination. As PD progresses, the amount of dopamine produced in the brain decreases, leaving a person unable to control movement normally. Objective of this research to drive neuron progenitor stem cell from adipose to treat Parkinson. Adipose was isolation from patient and cultur become neuron progenitor stem cell, after second passage the neuron progenitor stem cell was harvesting . Neuron progenitor stem cell was characterized by Noch1 flowcitrometry and LDopa Icc. Neuron progenitor stem cell was produce dopamine ready implant for Parkinson patient by direct implantation. Result: Ten patients with Parkinson diseases with inclusion and exclusion criteria, received neuron progenitor cell implantation, 2 patients no significant improvement and 8 patients have significant improvement, outcome evaluating using mRS (Modified Ranking Scale) and BI (Barthel index ). Conclusion: Neuron progenitor stem cell has significant improvement for Parkinson diseases
