Chinese Academy of Sciences, China
Title: Identify the melocular mechamisms that regulate defective NK cell development in aged mice
Biography: Min Fang
Natural killer (NK) cells are bone marrow-derived lymphocytes crucial for host defense against several infections and cancer. We have previously shown that compared to young, aged C57BL/6 mice have decreased numbers of mature NK cells, resulting in susceptibility to mousepox, a lethal disease caused by ectromelia virus. We also found that the natural killer cell dysfunction of aged mice is due to the bone marrow stroma, not NK cell intrinsic. To investigate the melocular mechanisms that regulat the defective NK cell development in aged mice, we used high throughput sequencing to compare the gene expression differences between young and aged NK cells. We found that over 300 genes were differentially expressed in the aged NK cells compared to the youngs. Further identification of the main or check point regulators will shed new lights on the regulation of NK cell development in the aging enviroment.
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