Hung-Yun Lin
Taipei Medical University, Taiwan
Title: Induction of expression of pd-l1 by thyroid hormone interferes with resveratrol-induced antiproliferation in cancer cells
Biography
Biography: Hung-Yun Lin
Abstract
The checkpoint programmed cell death protein 1 (PD-1)/ programmed death-ligand 1(PD-L1) plays an important role in cancer proliferation. Thyroid hormone, L-thyroxine (T4), induces the expression of PD-L1 and promotes cell proliferation in cancer cells. Resveratrol inducesanti-proliferation in various types of cancer cells via binding to integrin αvβ3 to increase nuclear inducible cyclooxygenase (COX)-2 accumulation, complex with p53, and induce p53-dependent anti-proliferation. We investigated the mechanism by which L-thyroxine impairs resveratrolinduced anti-proliferation in human cancer cells. L-thyroxine increased expression and cytoplasmic accumulation of PD-L1. The increased PD-L1 retained resveratrol-induced COX- 2 in cytoplasm and prevented COX-2 nuclear accumulation. Byinhibiting activated PI-3K-STAT3 signal transduction axis by thyroid hormone, anodiamino-tetrac (NDAT) was able to inhibit thyroid hormone-induced PD-L1 and relieved the inhibitory effect of L-thyroxine on resveratrolinduced nuclear accumulation of COX-2. DAT is a thyroid hormone derivative. The NDAT-inhibited consequences were re-establishingCOX-2/p53-dependent gene expression and anti-proliferation. These findings provide new insights into the antagonizing effect of NDAT on L-thyroxineinduced interference withresveratrol-induced anticancer properties.