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Yang (Ted) D Teng

Yang (Ted) D Teng

Harvard Medical School, USA

Title: Therapeutic target identification by genetically engineered human neural stem cells in a spinal cord glioblastoma model

Biography

Biography: Yang (Ted) D Teng

Abstract

We  recently established a rodent model of intramedullary cervical spinal cord glioblastoma (ISCG). The system for the first time emulated both somatomotosensory disorders and autonomic dysfunctions of this deadly disease. Using genetically engineered human neural stem cells (hNSCs) that were capable to track and migrate towards the cancer cells we have determined a subpopulation of ISCG cells that are crucial for the tumor survival and could be targeted by therapeutic hNSCs that exerted a localized oncolytic effect. Importantly, the data also illuminated host spinal cord cellular and network components that should be preserved to maximize residual neural function in order to benefit extension of survival. Overall, our findings demonstrated a stem cellbased multimodal approach to developing targeted glioblastoma treatment. Such a strategy can be further optimized for its  comprehensive efficacy via a simultaneous application of targeted neuroprotection  treatment to sustain neurological function.