John W Rumsey
Hesperos, Inc, USA
Biography
John W Rumsey is leading and performing biomedical research in the areas of neural tissue engineering and cell metabolism serves as a foundation for research into establishing human-on-a-chip systems that mimic the structural, physiological and metabolic properties of the in-system tissues. He had experience in establishing models of spinal cord and sensory neuron myelination with node of Ranvier formation and contractile skeletal muscle myotubes. He also had experience in using photolithography and bioMEMs devices integrated with primary cells to direct growth, differentiation, and functional property maturation of neurons and muscle. Additionally, he has investigated the metabolic programming of skeletal muscle using in vivo and in vitro models, ultimately elucidating the role of the PGC-1 family of transcriptional co-activators in oxidative metabolic programming, fiber type determination and the endurance phenotype. At Hesperos, Inc. he had been involved in the development of human-on-a-chip models of physiology and disease using organ modules including cortical neurons, motoneurons, skeletal muscle, liver, cardiomyocytes, adipocytes, kidney and various barrier tissues. These human-on-a-chip model systems have been used for disease modeling and drug discovery purposes.
Abstract
Abstract : Stem cell based human on a chip models for drug efficacy safety and precision medicine